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Recording and Modulation of Epileptiform Activity in Rodent Brain Slices Coupled to Microelectrode Arrays
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BAD and KATP channels regulate neuron excitability and epileptiform activity

Juan Ramón Martínez-François1, María Carmen Fernández-Agüera2, Nidhi Nathwani1

  • 1Department of Neurobiology, Harvard Medical School, Boston, United States.

Elife
|January 26, 2018
PubMed
Summary

Altering BAD (BCL-2 agonist of cell death) impacts brain metabolism and enhances seizure resistance. This protection is linked to ATP-sensitive potassium (KATP) channels, particularly in dentate granule neurons.

Keywords:
Brain sliceCalcium imagingEpilepsyMetabolic seizure resistancemouseneuroscience

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