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Updated: Feb 15, 2026
Measurement of Energy Metabolism in Explanted Retinal Tissue Using Extracellular Flux Analysis
Published on: January 7, 2019
Resting energy metabolism and anticancer treatments
Anne Jouinot1,2, Clara Vazeille1, François Goldwasser1
1Medical Oncology Department, Cancer Research for PErsonalized Medicine (CARPEM), hôpital Cochin, Paris Centre Teaching Hospitals, Paris Descartes University, USPC.
Purpose Of Review:
Cachexia is a multifactorial syndrome associated with morbidity and mortality in cancer patients and represents a major challenge in cancer management. Elevated energy expenditure is supposed to contribute to cachexia. The current article presents the recent findings on the resting energy expenditure (REE) in cancer and the clinical implications for anticancer treatments.
Recent Findings:
Half of cancer patients present with hypermetabolism (measured REE >110% of predicted REE). Hypermetabolism is associated with clinical and biological features of cachexia. Hypermetabolic patients - even those with normal nutritional status - have a high risk of severe acute toxicity and a poor prognosis.
Summary:
Recent discoveries have highlighted the REE as an essential component of nutritional assessment in cancer patients. Multimodal care for cachexia should include REE measurements and dedicated pharmacologic interventions such as adrenoreceptor blockade in case of hypermetabolism.
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