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Primary spinal mucosa-associated lymphoid tissue lymphoma: A case report
Rongrong Dong1, Jiali Ji1, Hong Liu1
1Department of Medical Oncology, the Second Affiliated Hospital, Zhejiang University School of Medicine.
This study presents a rare case of spinal Mucosa-Associated Lymphoid Tissue (MALT) lymphoma in a 68-year-old woman. The patient achieved a favorable outcome with a combined surgical and systemic treatment approach, highlighting its potential efficacy for this indolent lymphoma.
Area of Science:
- Oncology
- Hematology
- Pathology
Background:
- Mucosa-associated lymphoid tissue (MALT) lymphoma is an indolent B-cell lymphoma typically affecting mucosal sites.
- Primary spinal MALT lymphoma is exceptionally rare, with limited reported cases and no established treatment guidelines.
- This study aims to contribute a successfully treated case to the literature and review current management strategies.
Observation:
- A 68-year-old female presented with back pain and progressive lower extremity weakness.
- Spinal MRI revealed a T6-T8 epidural mass causing cord compression, confirmed as MALT lymphoma via histology and immunohistochemistry.
- PET/CT identified metastases in the right iliac wing and liver.
Findings:
- The patient underwent surgical resection followed by six cycles of immuno-chemotherapy with intrathecal methotrexate and cytarabine.
- Histological and immunochemical analysis confirmed MALT lymphoma with specific cell markers (CD20+, CD21+, CD43+, bcl-2+) and a Ki-67 index of 15%.
Implications:
- The case demonstrates a favorable prognosis for spinal MALT lymphoma when treated with a multimodal approach including surgery and adjuvant systemic therapy.
- This supports the consideration of systemic treatments in managing rare spinal MALT lymphoma cases.
- Further research is needed to establish definitive treatment guidelines for this rare entity.
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