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Primary cutaneous anaplastic large-cell lymphoma: A case report
Medicine
|January 26, 2018
Summary
Primary cutaneous anaplastic large-cell lymphoma (C-ALCL) is a rare skin cancer. Prompt diagnosis and appropriate chemotherapy led to complete remission in a challenging case, highlighting the importance of accurate C-ALCL diagnosis.
Area of Science:
- Oncology
- Dermatology
- Hematology
Background:
- Primary cutaneous anaplastic large-cell lymphoma (C-ALCL) is a rare T-cell lymphoproliferative neoplasm.
- C-ALCL typically presents as solitary or multiple ulcerated skin lesions.
Observation:
- A 73-year-old male presented with a skin tumor initially misdiagnosed as discoid lupus erythematosus.
- Rapid tumor growth and progression prompted repeat biopsy, revealing pilomatrix carcinoma.
- Further histopathological analysis identified C-ALCL infiltration in the dermis and subcutaneous tissue.
Findings:
- The patient received chemotherapy at the Lymphoid Tumours Clinic.
- Complete remission of skin lesions was achieved after 4 cycles of chemotherapy.
- No recurrence was observed during a 5-year follow-up period.
Implications:
- Accurate diagnosis of C-ALCL is crucial to avoid misdiagnosis.
- Misdiagnosis can result in ineffective treatment, disease progression, and patient harm.
- This case underscores the importance of thorough histopathological evaluation for rare skin cancers.
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