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Updated: Feb 15, 2026

Activating Autophagy by Aerobic Exercise in Mice

Activating Autophagy by Aerobic Exercise in Mice

Published on: February 3, 2017

Autophagy and Longevity.

Shuhei Nakamura^1,2, Tamotsu Yoshimori^1,2

¹Department of Genetics, Graduate School of Medicine, Osaka University, Osaka, Japan.

Molecules and Cells

|January 27, 2018

Summary

This summary is machine-generated.

Autophagy, a cellular recycling process, is vital for maintaining cell health and extending animal lifespan. Activating autophagy through genetic or pharmacological means offers a promising strategy for longevity research.

Keywords:

C. elegans aging autophagy longevity transcription factors

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Activating Autophagy by Aerobic Exercise in Mice

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Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond

Live Cell Imaging of Early Autophagy Events: Omegasomes and Beyond

Published on: July 27, 2013

Area of Science:

Cellular Biology
Genetics
Aging Research

Background:

Autophagy is a conserved cellular degradation process essential for homeostasis.
Autophagic activity is elevated in many longevity paradigms and required for lifespan extension.
Genes regulating autophagy and lysosomal function are induced by transcription factors like TFEB in long-lived animals.

Purpose of the Study:

To summarize recent findings on the role of autophagy in regulating animal lifespan.
To highlight the connection between autophagy, transcription factors, and longevity.
To discuss the potential of autophagy as a therapeutic target for lifespan modulation.

Main Methods:

Review of recent genetic and pharmacological studies on autophagy and lifespan.
Analysis of transcription factor involvement (HLH-30/TFEB, PHA-4/FOXA, MML-1/Mondo) in autophagy-related longevity.
Synthesis of evidence linking basal autophagic activity to lifespan extension.

Main Results:

Autophagic activity is crucial for cellular homeostasis and animal lifespan.
Elevated autophagy is a common feature in various longevity models.
Pharmacological activation of autophagy can extend lifespan.

Conclusions:

Autophagy plays a critical role in the regulation of animal lifespan.
Targeting autophagy pathways presents a promising avenue for interventions aimed at increasing longevity.
Understanding the molecular mechanisms, including transcription factor regulation, is key to harnessing autophagy for lifespan extension.