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Related Concept Videos

Bone Structure01:55

Bone Structure

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Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
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Bone Remodeling01:40

Bone Remodeling

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Compact Bone01:27

Compact Bone

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Most bones contain compact and spongy osseous tissue, but their distribution and concentration vary based on the bone's overall function.
Compact bone, also called cortical bone, is the denser, stronger of the two types of bone tissue. It is found under the periosteum and in the diaphyses of long bones, where it provides support and protection. The microscopic structural unit of compact bone is called an osteon, or haversian system. Each osteon is composed of concentric rings of calcified...
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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The Hyoid Bone01:12

The Hyoid Bone

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The hyoid bone is a small U-shaped bone located in the upper neck at the level of the inferior mandible, with its tips pointing posteriorly. It does not directly articulate with any other bone in the body. The hyoid acts as the attachment site for the tongue, the larynx, and the pharynx. It is held in position by a series of small muscles attached from above or below. These muscles help to move the hyoid up/down or forward/back in coordination with movements of the tongue, larynx, and pharynx...
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Spongy Bone01:09

Spongy Bone

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All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...
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Related Experiment Video

Updated: Feb 15, 2026

Intravital Longitudinal Imaging of Vascular Dynamics in the Calvarial Bone Marrow
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Intravital Longitudinal Imaging of Vascular Dynamics in the Calvarial Bone Marrow

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[Intravital bone imaging:osteoclast.]

Junichi Kikuta1, Masaru Ishii1

  • 1Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Japan.

Clinical Calcium
|January 27, 2018
PubMed
Summary
This summary is machine-generated.

This study visualizes osteoclast activity in living bone using advanced imaging, revealing distinct bone-resorptive and non-resorptive states. Intravital imaging also tracked biologic drug effects on osteoclasts during inflammation.

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Models of Bone Metastasis
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Related Experiment Videos

Last Updated: Feb 15, 2026

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Area of Science:

  • Bone biology
  • Cellular dynamics
  • Microscopy techniques

Background:

  • Osteoclasts are crucial for bone resorption, differentiating from macrophage precursors.
  • Understanding osteoclast behavior in vivo is vital for bone disease research.

Purpose of the Study:

  • To establish and utilize an advanced imaging system for visualizing live osteoclast dynamics in bone.
  • To identify functional states and drug interactions of mature osteoclasts in vivo.

Main Methods:

  • Development of an intravital multiphoton microscopy system for live bone imaging.
  • Real-time observation of osteoclast behavior and bone resorption processes.
  • In vivo assessment of biologic drug effects on osteoclasts.

Main Results:

  • Successfully visualized the in vivo behavior of mature osteoclasts in living bone.
  • Identified two distinct functional states: 'bone-resorptive' and 'non-resorptive' osteoclasts.
  • Observed direct actions of biologic drugs on mature osteoclasts during inflammatory bone destruction.

Conclusions:

  • Intravital multiphoton microscopy provides unprecedented insights into osteoclast dynamics.
  • Osteoclasts exhibit distinct functional states influencing bone resorption.
  • This imaging approach is valuable for studying drug efficacy in inflammatory bone diseases.