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Biomolecule-embedded metal-organic frameworks as an innovative sensing platform
Sureshkumar Kempahanumakkagari1, Vanish Kumar2, Pallabi Samaddar3
1School of Basic and Applied Sciences, Daynanada Sagar University, Bengaluru 560078, India.
Biotechnology Advances
|January 29, 2018
Summary
Novel biomolecule-embedded metal-organic frameworks (MOFs) offer innovative sensing platforms. This review details MOF design and synthesis strategies for advanced biosensor applications.
Area of Science:
- Materials Science
- Biotechnology
- Nanotechnology
Background:
- Advancements in materials research yield novel substrates for biological, energy, and environmental applications.
- Embedding biomolecules in advanced materials like metal-organic frameworks (MOFs), nanoparticles, and graphene is a key area for developing innovative platforms.
- MOFs, with their unique properties, are crucial for progress in enzymatic catalysis, antibody-antigen interactions, and bioelectronic devices.
Purpose of the Study:
- To describe strategies for designing and synthesizing diverse biomolecule-embedded MOFs.
- To explore the application of these MOFs in various sensing techniques (optical, electrochemical, biological).
- To discuss the benefits and future prospects of MOF-based biomolecular immobilization for sensing.
Main Methods:
- Review of design and synthesis strategies for biomolecule-embedded MOFs.
- Analysis of MOF properties relevant to biomolecular immobilization.
- Evaluation of MOF-based sensing platforms across different techniques.
Main Results:
- Various strategies exist for creating biomolecule-embedded MOFs.
- MOFs demonstrate significant potential in enhancing enzymatic catalysis and biomolecular interactions.
- MOF-based platforms show promise for diverse sensing applications.
Conclusions:
- Biomolecule-embedded MOFs represent a vital and innovative platform for advanced sensing technologies.
- Further development and performance evaluation are crucial for realizing the full potential of MOF-based biosensors.
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