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Default Mode Network Changes in Moyamoya Disease Before and After Bypass Surgery: Preliminary Report
Yusuke Sakamoto1, Sho Okamoto1, Satoshi Maesawa2
1Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
World Neurosurgery
|January 29, 2018
Summary
Moyamoya disease disrupts the default mode network (DMN), impacting cognitive functions like working memory. Vascular reconstruction surgery may help normalize brain networks and improve cognition.
Area of Science:
- Neuroscience
- Radiology
Background:
- Moyamoya disease is associated with neurocognitive impairment.
- The default mode network (DMN) plays a crucial role in cognitive functions.
Purpose of the Study:
- To investigate default mode network (DMN) alterations in moyamoya disease using resting-state functional magnetic resonance imaging (rs-fMRI).
- To explore the association between DMN changes and neurocognitive impairments.
- To evaluate the impact of surgical treatment on DMN connectivity and cognition.
Main Methods:
- Seven moyamoya disease patients underwent rs-fMRI and neuropsychological testing.
- Group independent component analysis with dual regression compared patient RSNs to 127 healthy controls.
- Correlations between RSN alterations and cognitive scores were analyzed pre- and post-surgery.
Main Results:
- Patients with moyamoya disease showed significant differences in DMN connectivity compared to controls.
- Lower working memory and performance speed scores correlated with altered ventral DMN connectivity.
- Five patients who underwent vascular reconstruction surgery exhibited DMN connectivity resembling healthy controls post-surgery.
Conclusions:
- Disruption of the DMN in moyamoya disease is inversely correlated with working memory and performance speed.
- Vascular reconstruction surgery may facilitate the normalization of brain networks in moyamoya disease.
- Resting-state network analysis shows potential as a biomarker for cognitive function in moyamoya disease.
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