Related Experiment Video
Updated: Feb 15, 2026
Calibrated Forceps Model of Spinal Cord Compression Injury
Published on: April 24, 2015
Comparison of Two Radiotherapy Regimens for Metastatic Spinal Cord Compression: Subgroup Analyses from a Randomized
Dirk Rades1, Antonio J Conde-Moreno2, Jon Cacicedo3
1Department of Radiation Oncology, University of Lübeck, Lübeck, Germany rades.dirk@gmx.net.
Background/Aim:
According to our randomized trial, 5×4Gy was comparable to 10×3Gy for metastatic spinal cord compression. Since it remained unclear whether findings applied to poor and intermediate prognoses patients, subgroup analyses were performed.
Patients And Methods:
In patients with poor prognoses, 58 received 5×4Gy, 53 received 10×3Gy. In intermediate-prognoses patients, numbers were 43 and 49.
Results:
In patients with poor prognoses, 1-month overall response (OR) was 85% after 5×4Gy and 10×3Gy (p=0.99), improvement 38% vs. 42%, ambulatory status 60% vs. 64% (p=0.83), 6-month local progression-free survival (LPFS) 75% vs. 69% (p=0.74) and 6-month overall survival (OS) 26% vs. 19% (p=0.43). In patients with intermediate prognoses, 1-month OR was 89% after 5×4Gy and 93% after 10×3Gy (p=0.85), improvement 39% vs. 45%, ambulatory status 84% vs. 82% (p=0.90), 6-month LPFS 79% vs. 92% (p=0.17) and 6-months OS 65% vs. 58% (p=0.65).
Conclusion:
5×4Gy was not significantly inferior to 10x3Gy in both subgroups.
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