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Updated: Feb 15, 2026

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids
Published on: May 4, 2018
Unique antimicrobial spectrum of ophiobolin K produced by Aspergillus ustus
Natthapat Sohsomboon1, Hiroshi Kanzaki1, Teruhiko Nitoda1
1a Graduate School of Environmental and Life Science , Okayama University , Okayama , Japan.
Abstract:
A co-cultivation study of two fungal strains showed that Aspergillus ustus could inhibit Aspergillus repens growth. The bioactive compound responsible for the observed activity was purified and identified as a sesterterpene, ophiobolin K. Ophiobolin K exhibited marked inhibition against both fungi and bacteria, especially A. repens, A. glaucus and gram-positive bacteria including Bacillus subtilis, Staphylococcus aureus, and Micrococcus luteus.
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