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Environment-Adaptive Coassembly/Self-Sorting and Stimulus-Responsiveness Transfer Based on Cholesterol Building

Pengyao Xing¹, Huijun Phoebe Tham¹, Peizhou Li¹

¹Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences Nanyang Technological University 21 Nanyang Link 637371 Singapore Singapore.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

|January 30, 2018

Summary

Researchers achieved switchable property transfer in nanosystems by controlling molecular packing. Two components, cholesterol conjugated cyanostilbene (CCS) and C10CN, demonstrated self-sorting and coassembly, leading to stimuli-responsive materials.

Keywords:

cholesterol coassembly nanostructures property transfer stimulus responsiveness

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Area of Science:

Supramolecular Chemistry
Materials Science
Nanoscience

Background:

Controlling property transfer in nanosystems requires tunable molecular packing, like self-sorting or coassembly.
Developing switchable, stimulus-responsive materials is crucial for advanced applications.

Purpose of the Study:

To investigate unique manipulation of self-sorting/coassembly aggregation.
To observe switchable stimulus-responsiveness transfer in a two-component self-assembly system.

Main Methods:

Synthesized two building blocks: cholesterol conjugated cyanostilbene (CCS) and C10CN (cholesterol with naphthalimide).
Investigated their aggregation behavior in polar and nonpolar solvents, forming gels, crystalline plates, and vesicles.
Analyzed stimuli-responsive properties (light and thermal) of individual components and coassembled systems.

Main Results:

Self-sorting dominated in gel and crystalline plate phases, while synergistic coassembly occurred in vesicles.
CCS exhibited light-induced chiral amplification; C10CN showed thermoresponsive inversion of supramolecular chirality.
In coassembled vesicles, responsiveness was transferred: C10CN became light-sensitive and CCS thermoresponsive.

Conclusions:

Demonstrated unprecedented property transfer between self-assembled components.
Highlighted the potential for precise fabrication of smart materials with switchable responsiveness.