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[Research progress of Chinese herbs inhibiting NADPH oxidase]

Qing Zhang1, Li-Shan Zhou2, Hui Dong1

  • 1Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
|January 30, 2018
PubMed

Insights

Chinese herbs inhibit NADPH oxidase, reducing oxidative damage and reactive oxygen species (ROS) generation. This offers potential antioxidant treatments for diseases linked to ROS, including cardiovascular and neurological conditions.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Traditional Chinese Medicine

Background:

  • Oxidative damage from abnormal NADPH oxidase activation and excessive reactive oxygen species (ROS) generation underlies numerous diseases.
  • Conditions like tissue injury, vascular and nerve damage, atherosclerosis, ischemia-reperfusion, hypertension, and hyperglycemia are linked to this oxidative stress.

Purpose of the Study:

  • To review Chinese herbs with inhibitory effects on NADPH oxidase.
  • To elucidate the mechanisms by which these herbs target NADPH oxidase for therapeutic benefit.

Main Methods:

  • Literature review of studies on Chinese herbs (monomers, compounds, patent medicines) and their NADPH oxidase inhibitory activity.
  • Analysis of proposed mechanisms of action for NADPH oxidase inhibition by various herbal formulations.

Main Results:

  • Identified various Chinese herbs and their preparations demonstrating NADPH oxidase inhibitory potential.
  • Summarized the diverse molecular targets and pathways involved in the inhibition of NADPH oxidase by these herbs.

Conclusions:

  • Chinese herbs represent a promising source of novel therapeutics for conditions associated with oxidative stress.
  • Targeting NADPH oxidase with Chinese herbal medicine offers a viable strategy for managing a range of pathological conditions.
Keywords:
Chinese herbsNADPH oxidasereactive oxygen species

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