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Drug delivery targets and systems for targeted treatment of rheumatoid arthritis

Xun Feng1, Yang Chen2

  • 1a Department of Sanitary Inspection, School of Public Health , Shenyang Medical College , Shenyang , China.

Journal of Drug Targeting
|January 30, 2018
PubMed

Insights

Targeted drug delivery shows promise for rheumatoid arthritis (RA) treatment, minimizing side effects. This review explores RA targets and nanotech-based delivery systems for enhanced joint inflammation therapy.

Area of Science:

  • Immunology
  • Pharmacology
  • Biotechnology

Background:

  • Rheumatoid arthritis (RA) is an immune-mediated inflammatory joint disease.
  • Conventional treatments for RA often cause significant side effects and systemic complications.
  • Targeted drug delivery strategies are emerging as a promising alternative for RA management.

Purpose of the Study:

  • To review potential molecular targets within the inflamed synovium for RA treatment.
  • To present various drug delivery systems designed for targeted RA therapy.
  • To highlight the synergy of nanotechnology and active targeting for RA.

Main Methods:

  • Literature review of RA-specific molecular targets.
  • Analysis of drug delivery systems including liposomes, nanoparticles, micelles, and prodrugs.
  • Examination of ligand-mediated active targeting strategies combined with nanomedicine.

Main Results:

  • Identified key targets: folate receptor, angiogenesis, MMPs, selectins, VIPR, and Fc-γ receptor.
  • Cataloged diverse nanocarriers and macromolecular prodrugs for targeted delivery.
  • Demonstrated the potential of combining nanotechnology with active targeting for RA.

Conclusions:

  • Targeted therapies offer a more specific approach to treating RA, reducing systemic toxicity.
  • Nanotechnology-based delivery systems show significant potential for improving RA treatment efficacy.
  • Further research into targeted drug delivery is crucial for advancing RA patient care.
Keywords:
Targeted drug deliverynanoparticlesnanotechnologyrheumatoid arthritis

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