Related Experiment Video
Updated: Feb 15, 2026
09:06
Evaluation of the Curing of Adhesive Systems by Rheological and Thermal Testing
Published on: July 3, 2020
7.8K
Targeting minimal residual disease: a path to cure?
Marlise R Luskin1, Mark A Murakami1, Scott R Manalis2
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.
Nature Reviews. Cancer
|January 30, 2018
Summary
Targeting minimal residual disease (MRD) is crucial for cancer cure. New single-cell methods can detect and predict MRD sensitivity, potentially improving patient outcomes and leading to remission.
Area of Science:
- Oncology
- Cancer Therapeutics
- Immunology
Background:
- Cancer treatments targeting kinases, transcriptional modifiers, and immune checkpoints are revolutionizing care.
- Many patients achieve remission but retain minimal residual disease (MRD), leading to relapse.
Purpose of the Study:
- To explore novel functional approaches for characterizing clonal heterogeneity.
- To predict the therapeutic sensitivity of MRD at a single-cell level.
Main Methods:
- Utilizing advanced single-cell analysis techniques.
- Developing methods for iterative detection and profiling of MRD.
Main Results:
- Demonstrated the ability to characterize MRD heterogeneity.
- Showcased potential for predicting MRD therapeutic sensitivity.
Conclusions:
- Iterative detection, profiling, and targeting of MRD show promise for improving cancer treatment outcomes.
- These approaches may lead to a functional cure for cancer by eradicating MRD.
Related Concept Videos
01:22Mean free path and Mean free time
5.3K
Consider the gas molecules in a cylinder. They move in a random motion as they collide with each other and change speed and direction. The average of all the path lengths between collisions is known as the "mean free path."
5.3K
01:20Curing of Concrete
378
The hydration of cement takes place within the water-filled capillary pores. However, environmental elements can disrupt this process by evaporating water from the concrete surfaces. Sealed concrete with a water-cement ratio below 0.5 experiences self-desiccation, leading to water loss. The water loss in concrete is mitigated by curing. This technique involves keeping the concrete saturated to maintain the necessary temperature and moisture conditions, to optimally fill the spaces in the cement...
378
01:26Curing Methods
310
Concrete members with a small surface-to-volume ratio are cured by oiling and moistening the forms before casting the concrete member. These forms can be left in place for a prolonged period to prevent moisture loss, and can be wetted if made of a material suitable for wetting. If the forms are removed early, the concrete member is moistened and covered with polythene sheets to maintain moisture. For large horizontal concrete surfaces exposed to dry weather, a temporary covering is suspended...
310
01:07Residual Plots
6.5K
A residual plot is a statistical representation of data used to analyze correlation and regression results. It helps verify the requirements for drawing specific conclusions about correlation and regression. To obtain the residual plot, first, the residual for each data value is calculated, which is simply the vertical distance between the observed and the predicted value obtained from the regression equation.
When the residual values are plotted against the variable x, it is called a residual...
When the residual values are plotted against the variable x, it is called a residual...
6.5K
01:21Path Between Thermodynamics States
4.1K
Consider the two thermodynamic processes involving an ideal gas that are represented by paths AC and ABC in Figure 1:
4.1K
01:26Residual Stresses
671
Residual stresses reside in a structure even after removing the original stress inducer. This phenomenon often arises from varied plastic deformations across different parts of a structure. Consider a rod stretched beyond its yield point. It will not regain its original length due to permanent deformation. Even after load removal, the rod does not entirely lose stress because of uneven plastic deformations, resulting in residual stresses. The computation of these stresses in structures is...
671