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Validation of the Delayed Matching-to-Sample Task 48 (DMS48) in Elderly Chinese
Xueyan Feng1, Aihong Zhou1,2,3,4,5, Zhixin Liu6
1Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, P.R. China.
Journal of Alzheimer'S Disease : JAD
|January 30, 2018
Summary
The Delayed Matching-to-Sample Task 48 (DMS48) effectively screens for early Alzheimer's disease in Chinese elders. This study provides age-specific norms and cutoff points for accurate diagnosis in this population.
Area of Science:
- Neurology
- Gerontology
- Psychometrics
Background:
- The Delayed Matching-to-Sample Task 48 (DMS48) is a validated tool for detecting early Alzheimer's disease (AD) in Caucasian populations.
- Limited data exists on the DMS48's utility in Chinese elderly populations.
Purpose of the Study:
- To establish normative data and optimal cutoff points for the DMS48 specifically for Chinese elders.
- To validate the DMS48's effectiveness in identifying early-stage cognitive impairment in this demographic.
Main Methods:
- A cross-sectional study involving 369 Chinese participants aged 50+ (cognitively normal, mild cognitive impairment due to AD, and mild AD dementia) across seven memory clinics.
- Demographic factors influencing DMS48 scores were analyzed, and age-stratified norms were developed.
- Receiver operating characteristic (ROC) analysis was employed to determine optimal cutoff scores for differentiating cognitive states.
Main Results:
- Age significantly impacted DMS48 scores (r = -0.36, p < 0.05). Age-stratified normative data were established.
- Optimal cutoff scores were identified: 42/43 for distinguishing cognitive impairment (MCI-A and AD dementia) from cognitively normal (CN) individuals (97.80% sensitivity, 89.13% specificity).
- A cutoff of 39/40 demonstrated high sensitivity (100.00%) and specificity (94.90%) for differentiating AD dementia from CN. Age-specific cutoffs for MCI-A were also determined.
Conclusions:
- The DMS48 demonstrates good validation for screening mild cognitive impairment due to AD (MCI-A) in elderly Chinese individuals.
- The developed age-stratified norms and cutoff points enhance the DMS48's utility in clinical settings for Chinese populations.
- This research supports the DMS48 as a valuable tool for early Alzheimer's disease detection in China.
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