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Pediatric Invasive Candidiasis: Epidemiology and Diagnosis in Children

William J Steinbach1,2

  • 1Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA. bill.steinbach@duke.edu.

Journal of Fungi (Basel, Switzerland)
|January 30, 2018
PubMed

Insights

Epidemiology of invasive candidiasis in children differs from adults due to varied conditions and treatments. Further research on pediatric-specific diagnostics and antifungal treatments is crucial for effective patient care.

Area of Science:

  • Medical Mycology
  • Pediatric Infectious Diseases
  • Clinical Epidemiology

Background:

  • Invasive candidiasis epidemiology varies between pediatric and adult populations.
  • Pediatric patients have unique underlying conditions and cytotoxic therapies.
  • Understanding Candida species is vital for empiric antifungal therapy.

Purpose of the Study:

  • To review antifungal treatment for pediatric candidiasis.
  • To contextualize treatment within broader epidemiologic studies.
  • To highlight the need for pediatric-specific guidance.

Main Methods:

  • Review of existing epidemiologic studies on invasive candidiasis.
  • Analysis of available clinical trial data for pediatric antifungal treatment.
  • Assessment of newer molecular diagnostic assay reports.

Main Results:

  • Significant differences exist in invasive candidiasis epidemiology in children versus adults.
  • Limited pediatric-specific clinical trials and diagnostic assay data are available.
  • Current antifungal treatment strategies are reviewed.

Conclusions:

  • Pediatric invasive candidiasis requires tailored approaches due to differing epidemiology.
  • More research is needed on pediatric-specific molecular diagnostics.
  • Evidence-based pediatric-specific antifungal treatment guidance is lacking.

Keywords:
Candidaantifungalcandidiasisdiagnosispediatric

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