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Association between periodontitis and chronic kidney disease: Systematic review and meta-analysis
S Deschamps-Lenhardt1,2, R Martin-Cabezas1,2, T Hannedouche3
1Faculté de chirurgie-dentaire, Periodontology, Université de Strasbourg, Strasbourg, France.
Oral Diseases
|January 30, 2018
Summary
Periodontitis (PD), a gum disease, is significantly associated with chronic kidney disease (CKD). Further research is needed to determine if treating PD can improve CKD outcomes.
Area of Science:
- Oral Health
- Nephrology
- Systematic Review and Meta-Analysis
Background:
- Chronic kidney disease (CKD) affects millions globally, with increasing prevalence.
- Periodontitis (PD), a common oral infection, has been anecdotally linked to systemic conditions.
Purpose of the Study:
- To systematically review and meta-analyze the association between periodontitis and chronic kidney disease.
- To explore the potential impact of periodontal treatment on patients with CKD.
Main Methods:
- Systematic review and meta-analysis of studies published until December 2017.
- Databases searched included PubMed, Web of Science, Science Direct, and Cochrane.
- 37 articles were included in the review; 17 in the meta-analysis.
Main Results:
- Most studies indicated a higher incidence of PD in CKD patients.
- Meta-analysis confirmed a significant association between CKD and PD (OR=2.39 for severe PD).
- This association remained significant after adjusting for CKD risk factors (OR=2.26 for severe PD).
Conclusions:
- Periodontitis is demonstrably associated with chronic kidney disease.
- Further investigation is required to ascertain if periodontal intervention can mitigate CKD incidence or severity.
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