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Microparticles as prognostic biomarkers in dengue virus infection

Rucha Patil1, Smrati Bajpai2, Kanjaksha Ghosh3

  • 1National Institute of Immunohaematology (ICMR), 13th Floor, KEM Hospital, Parel, Mumbai 400 012, India.

Acta Tropica
|January 30, 2018
PubMed

Insights

Cell-derived microparticles (MPs) show promise as biomarkers for dengue virus infection (DVI). Platelet MPs may guide transfusion decisions, while red blood cell MPs could identify severe cases needing immediate care.

Area of Science:

  • Virology
  • Immunology
  • Hematology

Background:

  • Predicting severe dengue virus infection (DVI) requires reliable biomarkers.
  • Cell-derived microparticles (MPs) are emerging as potential indicators in various diseases.

Purpose of the Study:

  • To investigate the role of microparticles (MPs) in dengue virus infection (DVI).
  • To assess specific MPs as potential biomarkers for DVI severity and patient management.

Main Methods:

  • Analyzed annexinV, platelet (CD41a), red blood cell (RBC) (CD235a), and activated endothelial (CD62e) MPs.
  • Compared MP levels in 60 DVI patients (including dengue with warning signs, dengue shock syndrome, and dengue without warning signs) and 15 controls.

Main Results:

  • Elevated platelet MP (PMP) levels in patients with profound thrombocytopenia without bleeding versus those with bleeding (p < .001).
  • Significantly higher RBC MPs in the second phase of DWS patients by day 4 (≥2200 MPs/μl) compared to DWOS patients (p < .0001).

Conclusions:

  • Platelet MPs could be novel biomarkers to differentiate patients requiring prophylactic platelet transfusion.
  • RBC MPs may identify severe dengue cases needing urgent medical attention.
  • Microparticles show significant potential as biomarkers across various aspects of DVI.
Keywords:
BiomarkersCell-Derived microparticlesDenguePlateletsRed blood cells

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