Pharmacokinetics of Tedizolid in an Obese Patient after Bariatric Surgery
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Updated: Feb 15, 2026

Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice
Published on: October 18, 2024
Matthieu Grégoire1,2, Julia Brochard Libois3, Denis Waast4
1Clinical Pharmacology Department, CHU Nantes, Nantes, France matthieu.gregoire@chu-nantes.fr.
Abstract:
An obese woman was treated with oral tedizolid 200 mg once daily for pseudoarthrosis 10 years after Roux-en-Y bypass surgery. Total plasma peak concentration was 2.12 mg/liter 3 h after intake, and area under the concentration-time curve from 0 to 24 h (AUC0-24) was 28.3 mg/liter · h. The AUC0-24/MIC ratio for unbound concentrations and for sensitive Staphylococcus and Streptococcus strains was ≥10.8, higher than the target ratio of 3. These results support the use of tedizolid without adjustment after bariatric surgery.
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