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(Mesenchymal) Stem Cell-Based Therapy in Cisplatin-Induced Acute Kidney Injury Animal Model: Risk of Immunogenicity

Ž Večerić-Haler1, A Cerar2, M Perše2

  • 1Department of Nephrology, University Medical Centre Ljubljana, SI-1000 Ljubljana, Slovenia.

Stem Cells International
|January 31, 2018
PubMed

Insights

Mesenchymal stem cells (MSCs) show promise for treating acute kidney injury (AKI), but their potential for immune response and tumor formation requires further investigation in preclinical models.

Area of Science:

  • Nephrology
  • Regenerative Medicine
  • Immunology

Background:

  • Acute kidney injury (AKI) pathogenesis is complex, involving local kidney and systemic effects.
  • No current pharmacological agent fully protects against cisplatin-induced nephrotoxicity.
  • Mesenchymal stem cells (MSCs) are explored for AKI treatment due to their therapeutic potential.

Purpose of the Study:

  • To critically review MSC transplantation in animal AKI models, focusing on cisplatin-induced models.
  • To summarize findings on MSC immunogenicity and tumorigenicity.
  • To highlight key concerns for future clinical translation.

Main Methods:

  • Literature review of animal studies on MSC transplantation for AKI.
  • Focus on studies utilizing cisplatin-induced AKI models.
  • Analysis of reported immunogenicity and tumorigenicity data.

Main Results:

  • MSCs exhibit immunosuppressive properties but can also elicit immune responses.
  • Tumorigenicity of transplanted MSCs in AKI models is infrequently studied.
  • Concerns regarding immunogenicity and tumorigenicity are significant for clinical application.

Conclusions:

  • MSC therapy for AKI warrants careful consideration of immune responses and tumor risk.
  • Further research is essential to address immunogenicity and tumorigenicity concerns.
  • Preclinical data is crucial for guiding safe and effective clinical trials of MSCs in AKI.

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