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Behaviors are actions that an organism engages in—they can be related to finding food, reproducing, defending against threats, and many other possible actions. Behaviors include activities related to the environment around the animal—such as migration—as well as social interactions within a species or population. Many behaviors involve motor output—that is, muscle movements—while others involve less visible actions, such as learning.
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Behavioral Changes in Mice Lacking Interleukin-33.

Eisuke Dohi1, Eric Y Choi1, Indigo V L Rose1

  • 1Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287.

Eneuro
|January 31, 2018
PubMed
Summary
This summary is machine-generated.

Mice lacking Interleukin-33 (IL-33) showed reduced anxiety and impaired social recognition. This suggests IL-33 influences brain development and neuronal circuit maturation, not just adult neuronal activity.

Keywords:
IL-33anxietyastrocytescytokinesoligodendrocytessocial behavior

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Area of Science:

  • Neuroscience
  • Immunology
  • Behavioral Science

Background:

  • Interleukin-33 (IL-33) is an IL-1 family cytokine involved in inflammation.
  • IL-33 is present in the brain and linked to neuroinflammation and neurodegeneration.
  • The role of IL-33 in normal brain function and behavior is not well understood.

Purpose of the Study:

  • To investigate the behavioral effects of Interleukin-33 (IL-33) deficiency in mice.
  • To explore the role of IL-33 in physiological brain function and behavior.

Main Methods:

  • Behavioral testing of Interleukin-33 knockout (IL33-/-) mice using elevated plus maze (EPM), open field test (OFT), and three-chamber social interaction test.
  • Analysis of c-Fos protein immunoreactivity in brain regions associated with anxiety and social behavior.

Main Results:

  • IL33-/- mice displayed reduced anxiety-like behaviors in EPM and OFT.
  • These mice also showed deficits in social novelty recognition but maintained normal sociability.
  • Altered c-Fos expression in anxiety-related brain regions (mPFC, amygdala, PCX) was observed in IL33-/- mice post-EPM.

Conclusions:

  • Mice lacking IL-33 exhibit significant behavioral deficits, including reduced anxiety and impaired social recognition.
  • These findings suggest IL-33 plays a role in the development or maturation of neuronal circuits.
  • IL-33's primary function may be developmental rather than controlling adult neuronal activity.