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Updated: Feb 15, 2026

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
Published on: April 2, 2012
Reactivation of herpes simplex viral keratitis following the botulinum toxin injection
Muralidhar Ramappa1, Peter Y Jiya2, Sunita Chaurasia1
1Tej Kohli Cornea Institute; Jasti V Ramanamma Children's Eye Care Center, Hyderabad, India.
Abstract:
We describe a case of 55-year-old male farmer presented with recurrent corneal abrasions with a spastic entropion in the left eye. Superior cornea showed typical nummular opacities suggestive resolved herpetic eye diseases. On further enquiry, he had similar episodes in the past. Contralateral eye was essentially normal. Following the botulinum toxin injection for the management of spastic entropion, subject developed reactivation of herpetic necrotizing stromal keratitis. Diagnostic corneal scrapings were negative for herpes simplex virus-1 antigen by immunofluorescence assay and for DNA by molecular techniques. The case was successfully managed with topical steroids and antiviral medications.
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