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Updated: Feb 15, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
Published on: February 28, 2012
WATCHMAN device-related thrombus successfully treated with apixaban: A case report
Chun-Ka Wong1, Pak-Hei Chan, Cheung-Chi Lam
1Cardiology Division, Department of Medicine, The University of Hong Kong Cardiology Center, Hong Kong Sanatorium and Hospital, Happy Valley Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, China.
A short course of apixaban effectively resolved device-related thrombus in a patient with atrial fibrillation after left atrial appendage occlusion. This finding offers a potential treatment strategy for this complication, though further trials are needed.
Area of Science:
- Cardiology
- Interventional Cardiology
- Medical Device Technology
Background:
- Left atrial appendage occlusion (LAAO) is an alternative to anticoagulation for stroke prevention in atrial fibrillation patients at high bleeding risk.
- Device-related thrombus (DRT) is a significant complication of LAAO, potentially leading to recurrent embolic events.
- Optimal management strategies for DRT remain undefined, highlighting a critical unmet clinical need.
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