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Updated: Feb 15, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma mRCC in Mice Following Nephrectomy
Published on: April 29, 2014
Metastatic renal cell carcinoma initially presenting with hematochezia and subsequently with vaginal bleeding: a case
Simon Ouellet1, Audrey Binette2, Alexander Nguyen3
1Department of Surgery, Division of Urology, Université de Sherbrooke, Centre Hospitalier Universitaire de Sherbrooke (CHUS), 3001 12e avenue Nord, Sherbrooke, QC, J1H 5N4, Canada. simon.ouellet3@usherbrooke.ca.
Background:
We report an unusual case of a synchronous rectal and metachronous vaginal metastatic renal cell carcinoma.
Case Presentation:
A 78-year-old woman presented with hematochezia and a colonoscopy revealed a metastatic clear-cell renal cell carcinoma rectal polyp biopsy-proven. Abdominal computed tomography identified a 9.0-cm left renal mass with renal vein thrombosis, for which she underwent a laparoscopic radical nephrectomy. Histopathological examination confirmed a pT3a clear-cell renal cell carcinoma. Seven months later, the patient presented with vaginal bleeding. Physical examination revealed a vaginal polypoid mass and biopsy confirmed a clear-cell renal cell carcinoma metastasis.
Conclusions:
This case represents unusual manifestations of metastatic renal cell carcinoma and is a reminder of the wide spectrum of clinical course of this disease.
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