[Mixed lymphocyte culture as a compatibility test for bone marrow transplantation]

The reactions in mixed lymphocyte culture (MLC) between family members from 35 healthy families and 80 families of potential bone marrow recipients are shown. From the low MLC reactions seen in 128 pairs of HLA identical siblings, the limit of "Negative Reaction in Mixed Lymphocyte Culture" valid for our own laboratory can now be defined. The importance of mixed lymphocyte culture as a histocompatibility test for bone marrow transplantation is discussed.