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Treatment with Botulinum Toxin for Refractory Fever Caused by Severe Spasticity: A Case Series
Jacobo Lester1, Gerardo Esteban Alvarez-Resendiz2, Enrique Klériga3
1Neurology/Movement Disorders, Instituto Mexicano de Neurociencias, Hospital Angeles Lomas, Huixquilucan, Estado de México, Mexico. jacobolester@hotmail.com.
Introduction:
Brain and spinal cord injuries may cause very severe spasticity that occasionally may be associated with persistent fever.
Case Series:
We present 14 patients with spasticity and persistent fever, treated with botulinum toxin type A. Their spasticity improved and the fever resolved within a period no greater than 48 h. In all cases, infectious and other non-infectious causes were ruled out.
Conclusions:
When sustained tonic muscular activity is associated with a significant increase in body temperature and is refractory to the usual drugs used for hyperpyrexia, type A botulinum toxin may be an effective treatment option to control both spasticity and fever.
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