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Preparation of Rat Sciatic Nerve for Ex Vivo Neurophysiology
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Paralysis of the external popliteal sciatic nerve associated with daptomycin administration
L Villaverde Piñeiro1, R Rabuñal Rey2, A García Sabina1
1Department of Pharmacy, Lucus Augusti University Hospital, Lugo, Spain.
Journal of Clinical Pharmacy and Therapeutics
|February 1, 2018
Summary
Daptomycin use can lead to peripheral neuropathy, a rare side effect. This case highlights peroneal nerve involvement, suggesting a need for awareness of this specific daptomycin adverse event.
Area of Science:
- Neurology
- Pharmacology
Background:
- Peripheral neuropathy is a known adverse effect of certain medications.
- Limited reports link daptomycin to peripheral neuropathy, with no prior cases of peroneal nerve involvement.
Observation:
- A 62-year-old male patient developed external popliteal sciatic nerve paralysis.
- This occurred after 22 days of daptomycin therapy.
Findings:
- This case represents an uncommon and previously unreported adverse event associated with daptomycin.
- Analysis suggests potential involvement of ABCB1 gene polymorphisms in drug-induced adverse events.
Implications:
- Clinicians should be aware of the potential for daptomycin-induced peroneal nerve paralysis.
- Further research into genetic factors like ABCB1 polymorphisms may elucidate individual susceptibility to drug side effects.
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