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Building a developmental toxicity ontology
Nancy Baker1, Alan Boobis2, Lyle Burgoon3
1Lockheed Martin, Research Triangle Park, Piedmont, North Carolina.
Background:
As more information is generated about modes of action for developmental toxicity and more data are generated using high-throughput and high-content technologies, it is becoming necessary to organize that information. This report discussed the need for a systematic representation of knowledge about developmental toxicity (i.e., an ontology) and proposes a method to build one based on knowledge of developmental biology and mode of action/ adverse outcome pathways in developmental toxicity.
Methods:
This report is the result of a consensus working group developing a plan to create an ontology for developmental toxicity that spans multiple levels of biological organization.
Results:
This report provide a description of some of the challenges in building a developmental toxicity ontology and outlines a proposed methodology to meet those challenges. As the ontology is built on currently available web-based resources, a review of these resources is provided. Case studies on one of the most well-understood morphogens and developmental toxicants, retinoic acid, are presented as examples of how such an ontology might be developed.
Discussion:
This report outlines an approach to construct a developmental toxicity ontology. Such an ontology will facilitate computer-based prediction of substances likely to induce human developmental toxicity.
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