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Regenerative Therapy for Fuchs Endothelial Corneal Dystrophy
Yu Qiang Soh1,2, Jodhbir S Mehta1,2,3,4
1Tissue Engineering and Stem Cell Group, Singapore Eye Research Institute, Singapore.
Cornea
|February 1, 2018
Summary
Descemet membrane transplantation (DMT) offers a promising alternative to endothelial keratoplasty (EK) for Fuchs endothelial corneal dystrophy (FECD). This novel approach may restore corneal health without requiring donor cells, reducing risks associated with graft rejection and immunosuppression.
Area of Science:
- Ophthalmology
- Regenerative Medicine
- Corneal Surgery
Background:
- Fuchs endothelial corneal dystrophy (FECD) is a leading cause for corneal transplantation.
- Endothelial keratoplasty (EK) is the current standard surgical treatment for FECD.
- EK involves replacing diseased corneal tissue with donor tissue, carrying risks of rejection and requiring immunosuppression.
Observation:
- A first-in-human trial investigated Descemet membrane transplantation (DMT) as an alternative to EK for FECD.
- The study presented a case report of a patient with FECD treated with DMT.
Findings:
- The patient showed significant improvement in visual acuity and corneal endothelial cell density post-DMT.
- Central corneal thickness normalized, and the patient achieved stability without immunosuppressants.
- No major complications were observed during the follow-up period.
Implications:
- DMT may provide an effective treatment for FECD by promoting endothelial regeneration.
- This approach could potentially eliminate the need for allogeneic endothelial cell transplantation.
- DMT may reduce the risks of graft rejection and chronic immunosuppression associated with EK.
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