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Prenatal phthalate exposure was associated with croup in Swedish infants

Huan Shu1, Sverre Wikstrom2, Bo A G Jönsson3

  • 1Department of Health Sciences, Karlstad University, Karlstad, Sweden.

Acta Paediatrica (Oslo, Norway : 1992)
|February 1, 2018
PubMed

Insights

Prenatal exposure to butyl-benzyl phthalate (BBzP) and di-ethyl-hexyl phthalate (DEHP) is linked to infant croup. This association was dose-dependent and more pronounced in infant boys.

Area of Science:

  • Environmental Health
  • Pediatrics
  • Toxicology

Background:

  • Prenatal exposure to endocrine-disrupting chemicals is a growing concern.
  • Phthalates are commonly used plasticizers with potential health implications.

Purpose of the Study:

  • To investigate the association between prenatal phthalate exposure and infant respiratory conditions.
  • Specifically examining links to croup, wheezing, and otitis media.

Main Methods:

  • Analysis of 14 phthalate metabolites and one replacement in maternal urine (n=1062) during pregnancy.
  • Logistic regression used to assess associations with infant outcomes until 12 months of age.
  • Measurements adjusted for creatinine and potential confounders.

Main Results:

  • Significant associations found between butyl-benzyl phthalate (BBzP) and di-ethyl-hexyl phthalate (DEHP) metabolites and infant croup.
  • A dose-response relationship was observed for prenatal phthalate exposure and reported croup.
  • Associations were more significant in infant boys.

Conclusions:

  • Prenatal exposure to BBzP and DEHP phthalates is associated with an increased risk of croup in infants.
  • No clear associations were found with wheezing or otitis media.
  • Findings highlight the potential impact of phthalates on infant respiratory health.
Abstract

Keywords:
CroupExposurePhthalatePregnantSELMA study

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