Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmaceutical Equivalents01:26

Pharmaceutical Equivalents

208
As defined by regulatory standards, pharmaceutical equivalents require generic drug products to have identical dosage forms and chemically identical active pharmaceutical ingredients (APIs). They must adhere to compendial or applicable standards for potency, content uniformity, disintegration times, and dissolution rates. In the case of modified-release dosage forms, variations in drug content are permissible as long as the delivered amount remains consistent with the innovator drug product.
208
Steel Manufacturing01:26

Steel Manufacturing

1.5K
Steel manufacturing is a multi-stage process that begins by smelting iron ore into cast iron in a blast furnace. This initial stage involves layering iron ore with coke, a type of fuel, and crushed limestone within the furnace. The coke is ignited with a high volume of air, leading to the creation of carbon monoxide, which acts to reduce the iron ore to pure iron.
During this smelting process, limestone plays a crucial role by forming slag. Slag captures impurities within the molten iron, such...
1.5K
Pharmaceutical Poisoning: Potential Scenarios01:26

Pharmaceutical Poisoning: Potential Scenarios

15
Pharmaceutical poisoning can occur through various channels, impacting an estimated 2 million hospitalized patients in the U.S. annually with serious adverse drug responses. These scenarios encompass both therapeutic uses, such as drug toxicity, where even standard dosages can lead to severe central nervous system depression, and non-therapeutic exposures, including accidental ingestion by children, and environmental and occupational exposures.Unintentional poisonings often involve exploratory...
15
Pharmaceutical Poisoning: Treatment Strategies01:26

Pharmaceutical Poisoning: Treatment Strategies

16
Treatment strategies for poisoning are a critical aspect of emergency medicine, focusing on preventing the absorption of toxins and enhancing their elimination. When a poisoning incident occurs, the first response is to halt exposure and decontaminate the patient, particularly through gastrointestinal (GI) methods if the poison was ingested.Gastrointestinal Decontamination Techniques:Activated charcoal is the cornerstone of GI decontamination. It works through adsorption, binding the toxin to...
16
Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence01:22

Pharmaceutical Alternatives: Stability-Related Therapeutic Nonequivalence

214
Generic intravenous (IV) drugs are considered bioequivalent to their branded counterparts due to their 100% bioavailability upon administration. However, variations in stability among different drug products can significantly influence their therapeutic performance, even if they are pharmaceutically equivalent.Cefuroxime, a prophylactic antimicrobial, is often used as a single-dose IV injection for patients undergoing coronary artery bypass grafting surgery. A 3 g dose typically provides...
214
Continuing Care01:25

Continuing Care

2.0K
Continuing care describes the variety of health, personal, and social services provided over a prolonged period. The need for continuing care is increasing because people are living longer. Many people do not have families or others to care for them. Continuing care is mainly for patients who are disabled, functionally dependent, or suffering from a terminal disease. It is available within institutional settings or in homes. Examples include nursing centers or facilities, assisted living,...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synergistic CRISPR-Cas and Nanozyme-Based Fluorescent Sensors for Ultrasensitive Heavy Metal Detection.

Critical reviews in analytical chemistry·2026
Same author

Focused Beam Reflectance Measurement as a Complementary Tool for Monitoring Disintegration and Drug Release Processes of Sustained-Release Formulations: A Preliminary Investigation.

Chemical & pharmaceutical bulletin·2026
Same author

Pathway-Aware Template-Based Retrosynthesis.

Journal of chemical information and modeling·2026
Same author

Self-Powered Microfluidic Device with Laser-Converted Graphene Electrodes for Immobilization-Free Electrochemical Detection of MPOX Virus DNA via Mismatch-Driven Nanocomplexes.

Small (Weinheim an der Bergstrasse, Germany)·2026
Same author

Polyvinyl alcohol-based hard capsules with enhanced mechanical strength and gas barrier properties by montmorillonite incorporation.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2026
Same author

Understanding Size Distributions during Lipid Nanoparticle Manufacturing through Mechanistic Modeling.

ACS omega·2026
Same journal

VOCs Adsorption and Exchange Properties in Bispidine-Based Mn(II) 1D CPs Made of Orthogonally Oriented Linear Chains.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Electrosynthesis of Glycine From Nitrate and Glyoxylic Acid Over a Bi<sub>2</sub>S<sub>3</sub> Nanosheets-Based Catalyst.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Symmetry Breaking in Achiral Porphyrins: Noncovalent Origins of Emergent Optical Activity.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Modulation of O<sub>2</sub> Affinity and Enzymatic Activity of Core‒Shell Structured Hemoglobin Nanoparticles.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Stepwise Synthesis of Tetrabenzotriazaporphyrins (TBTAPs) and Their Open 2- and 3-Ring Fragments.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same journal

Geometry-Based Neural-Network Prediction of Electron Localization Function Topology in Dense Hydrogen.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
See all related articles

Related Experiment Video

Updated: Feb 15, 2026

A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor
05:21

A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor

Published on: February 10, 2023

3.8K

Advanced Continuous Flow Platform for On-Demand Pharmaceutical Manufacturing.

Ping Zhang1, Nopphon Weeranoppanant2, Dale A Thomas3

  • 1Novartis Institute of Biomedical Research, 250 Massachusetts Avenue, Cambridge, MA, 02139, USA.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|February 1, 2018
PubMed
Summary
This summary is machine-generated.

This study presents a smaller, reconfigurable continuous flow pharmaceutical manufacturing platform for on-demand medicine production. The automated system efficiently synthesizes and formulates essential medicines meeting pharmacopeia standards.

Keywords:
active pharmaceutical ingredientscontinuous flow chemistryindustrial chemistrysynthetic methods

More Related Videos

Manufacturing, Control, and Performance Evaluation of a Gecko-Inspired Soft Robot
07:40

Manufacturing, Control, and Performance Evaluation of a Gecko-Inspired Soft Robot

Published on: June 10, 2020

16.1K
Reproducible Manufacturing of SPOT as a High-throughput Scaffold-based Culture Platform
06:22

Reproducible Manufacturing of SPOT as a High-throughput Scaffold-based Culture Platform

Published on: July 29, 2025

973

Related Experiment Videos

Last Updated: Feb 15, 2026

A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor
05:21

A Scalable Balz-Schiemann Reaction Protocol in a Continuous Flow Reactor

Published on: February 10, 2023

3.8K
Manufacturing, Control, and Performance Evaluation of a Gecko-Inspired Soft Robot
07:40

Manufacturing, Control, and Performance Evaluation of a Gecko-Inspired Soft Robot

Published on: June 10, 2020

16.1K
Reproducible Manufacturing of SPOT as a High-throughput Scaffold-based Culture Platform
06:22

Reproducible Manufacturing of SPOT as a High-throughput Scaffold-based Culture Platform

Published on: July 29, 2025

973

Area of Science:

  • Pharmaceutical Manufacturing
  • Chemical Engineering
  • Process Chemistry

Background:

  • Traditional batch pharmaceutical manufacturing presents challenges in terms of large production footprint and extended timelines.
  • Previous work established a refrigerator-sized continuous flow system for on-demand essential medicine production.

Purpose of the Study:

  • To report a second-generation, reconfigurable, and more compact continuous flow pharmaceutical manufacturing platform.
  • To demonstrate advances in reaction and purification equipment within the new system.
  • To showcase the system's capability in synthesizing specific pharmaceutical compounds and producing finished drug doses.

Main Methods:

  • Development of a second-generation continuous flow platform, 25% smaller by volume than the previous system.
  • Design of two compact, stand-alone units for synthesis and purification/formulation processes.
  • Automation of the system for efficient pharmaceutical production.

Main Results:

  • Successful synthesis of nicardipine hydrochloride.
  • Production of concentrated liquid doses of ciprofloxacin hydrochloride, neostigmine methylsulfate, and rufinamide.
  • All produced medicines met United States Pharmacopeia (USP) standards.

Conclusions:

  • The second-generation platform offers a viable, smaller-footprint alternative to batch manufacturing.
  • The automated system demonstrates efficient on-demand production of essential medicines.
  • This technology advances the potential for decentralized and accessible pharmaceutical manufacturing.