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G2S: a web-service for annotating genomic variants on 3D protein structures.
Juexin Wang1, Robert Sheridan2, S Onur Sumer2
1Department of Electrical Engineering & Computer Science and Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, MO 65211, USA.
Bioinformatics (Oxford, England)
|February 1, 2018
Summary
Genomic G2S (Genome to Structure) provides a web API for mapping genomic variants to 3D protein structures. This tool automates variant analysis by aligning genomic data with protein structures for better insights.
Area of Science:
- Genomics
- Structural Biology
- Bioinformatics
Background:
- Accurate mapping of genomic locations to 3D protein structures is crucial for analyzing genomic variants.
- Existing resources lack web APIs for programmatic access to this data.
Purpose of the Study:
- To introduce G2S, a real-time web API for automated mapping of genomic variants onto 3D protein structures.
- To enable programmatic access for integrating structural information into genomic variant analysis.
Main Methods:
- Developed a REST-inspired web API named G2S.
- Implemented functionality to align genomic locations, protein locations, or protein sequences to protein structures.
- Enabled retrieval of mapped residues from protein structures.
Main Results:
- G2S offers automated, real-time mapping of genomic variants to 3D protein structures.
- The API supports alignment of genomic locations, protein locations, and sequences.
- Mapped residues can be retrieved directly from protein structures.
Conclusions:
- G2S facilitates the integration of 3D structural data into genomic variant analysis.
- The tool enhances the utility of large-scale sequencing data by providing a programmatic interface.
- G2S is freely available, promoting its adoption in bioinformatics research.
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