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Impact evaluation of the routine hepatitis B vaccination program of infants in China
Mei Sun1,2, Chengyue Li1,2, Pingping Li1,2,3
1Research Institute of Health Development Strategies, Fudan University, 177 box, 130 Dong'an Road, Shanghai, China.
Insights
China's infant hepatitis B vaccination program significantly reduced new infections over time. Higher vaccination coverage correlated with lower incidence, showing the program's growing impact.
Area of Science:
- Public Health
- Infectious Disease Epidemiology
- Vaccinology
Background:
- Hepatitis B virus (HBV) infection poses a significant global health burden.
- Infant vaccination is a key strategy for HBV prevention.
Purpose of the Study:
- To evaluate the impact of China's routine infant hepatitis B vaccination program.
- To assess the relationship between vaccination coverage and HBV incidence.
Main Methods:
- Utilized data from China's National Network Direct Report System (2004-2010).
- Analyzed incidence of new hepatitis B infections and vaccination coverage.
- Employed Chi-square tests and Pearson correlation analysis.
Main Results:
- New infection incidence was significantly lower in children with complete vaccination coverage.
- Incidence decreased from 2004 to 2010 among 0-9-year-olds.
- Provinces with higher vaccination rates showed substantially lower infection incidence.
Conclusions:
- The routine infant hepatitis B vaccination program in China demonstrates increasing effectiveness.
- Program implementation and regional disparities require attention for optimal public health outcomes.
Background:
To evaluate the impact of the routine hepatitis B vaccination program of infants in China.
Methods:
The incidence of new hepatitis B infection and coverage with three doses of the vaccines by age groups and provinces were derived from the National Network Direct Report System of Infectious Disease during 2004-10. Chi square test and Pearson correlation analysis were used to analyze differences in incidence according to vaccination coverage and the relationship between the coverage with three doses and the incidence in different provinces.
Results:
The incidence of new infection was 8.96/100 000 among children with complete coverage (0-15 years old), which was significantly lower than that with partial or no coverage. Among 0-9-year-old children in 2010, the incidence of new infection was 6.36/100 000, which was significantly lower than 2004. Considering the impact of vaccination on cumulative incidence among 0-5-year-old children, a 2.2-fold greater incidence of new infection was observed in provinces with the lowest to the highest vaccination rate.
Conclusion:
The impact of the routine hepatitis B vaccination program of infants in China has become more apparent over time. Program implementation and regional disequilibrium should be payed attention to as well as the expanded program.
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