Related Experiment Video
Updated: Feb 15, 2026

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
Published on: February 17, 2018
Socioeconomic deprivation and mode-specific outcomes in patients with chronic heart failure
Klaus K Witte1, Peysh A Patel1, Andrew M N Walker1
1Multidisciplinary Cardiovascular Research Centre, The University of Leeds, Leeds, UK.
Insights
Socioeconomic deprivation in chronic heart failure patients increases mortality and hospitalisation risks, primarily from non-cardiovascular causes. This highlights disparities in healthcare outcomes for deprived populations.
Area of Science:
- Cardiology and Public Health
- Socioeconomic Determinants of Health
Background:
- Chronic heart failure (CHF) affects millions globally, with outcomes influenced by various factors.
- Socioeconomic status is increasingly recognized as a critical determinant of health, yet its specific impact on CHF patients requires further elucidation.
Purpose of the Study:
- To investigate the association between socioeconomic deprivation and adverse health outcomes in patients diagnosed with chronic heart failure (CHF).
- To quantify the relationship between deprivation levels and mortality, hospitalisation rates, and duration of hospital stays in a CHF cohort.
Main Methods:
- A prospective observational study involving 1802 CHF patients (left ventricular ejection fraction ≤45%) across four UK hospitals (2006-2014).
- Socioeconomic deprivation was measured using the UK Index of Multiple Deprivation (IMD).
- Associations were assessed with mode-specific mortality, hospitalisation, and cumulative hospitalisation duration over a 1-year follow-up period.
Main Results:
- A significant gradient in IMD scores was observed between the least and most deprived patient groups.
- Higher IMD scores correlated with increased all-cause mortality (6% per 10-unit increase) and non-cardiovascular mortality (9% per 10-unit increase), but not cardiovascular mortality.
- Deprivation was associated with higher all-cause hospitalisation rates and a 4% increase in cumulative hospitalisation duration per 10-unit IMD score increase.
Conclusions:
- Socioeconomic deprivation is a significant factor associated with adverse outcomes in chronic heart failure patients.
- The increased mortality and hospitalisation risk in deprived CHF patients appear driven by a higher burden of non-cardiovascular conditions.
- These findings underscore the need to address socioeconomic factors to improve CHF patient care and reduce health inequalities.
Objective:
To characterise the association between socioeconomic deprivation and adverse outcomes in patients with chronic heart failure (CHF).
Methods:
We prospectively observed 1802 patients with CHF and left ventricular ejection fraction (LVEF) ≤45%, recruited in four UK hospitals between 2006 and 2014. We assessed the association between deprivation defined by the UK Index of Multiple Deprivation (IMD) and: mode-specific mortality (mean follow-up 4 years); mode-specific hospitalisation; and the cumulative duration of hospitalisation (after 1 year).
Results:
A 45-point difference in mean IMD score was noted between patients residing in the least and most deprived quintiles of geographical regions. Deprivation was associated with age, sex and comorbidity, but not CHF symptoms, LVEF or prescribed drug therapy. IMD score was associated with the risk of age-sex adjusted all-cause mortality (6% higher risk per 10-unit increase in IMD score; 95% CI 2% to 10%; P=0.004), and non-cardiovascular mortality (9% higher risk per 10-unit increase in IMD score; 95% CI 3% to 16%; P=0.003), but not cardiovascular mortality. All-cause, but not heart failure-specific, hospitalisation was also more common in the most deprived patients. Overall, patients spent a cumulative 3.3 days in hospital during 1 year of follow-up, with IMD score being associated with the age-sex adjusted cumulative duration of hospitalisations (4% increase in duration per 10-unit increase in IMD score; 95% CI 3% to 6%; P<0.0005).
Conclusions:
Socioeconomic deprivation in people with CHF is linked to increased risk of death and hospitalisation due to an excess of non-cardiovascular events.
Related Concept Videos
Heart Failure II: Pathophysiology
Pathophysiology of Heart Failure
Heart Failure I: Introduction
Heart Failure VI: Adjunct Therapies
Heart Failure Drugs: Diuretics
Heart Failure V: Medical Management

