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Inflammatory Markers and Plasma Lipids in HIV Patients: A Correlation Analysis Study
Rudo Muswe1, Olav Oktedalen2, Danai T Zhou3
1Department of Chemical Pathology, University of Zimbabwe, Harare, Zimbabwe.
HIV infection increases coronary heart disease (CHD) risk, driven by inflammation. ART-naive patients show higher TNF-α/IL-10 ratios, indicating elevated CHD risk, potentially worsened by low HDL-C.
Area of Science:
- Cardiology
- Infectious Diseases
- Immunology
Background:
- HIV infection is linked to increased coronary heart disease (CHD) risk, even with treatment.
- Chronic inflammation and traditional risk factors contribute to HIV-associated CHD.
Purpose of the Study:
- To investigate the relationship between inflammatory markers and lipid profiles in HIV-positive patients.
- To assess CHD risk factors in patients on antiretroviral therapy (ART) versus ART-naive individuals.
Main Methods:
- 152 HIV-positive patients were studied, with 82% on ART.
- Assayed inflammatory markers (TNF-α, IL-10, hsCRP) and lipids.
- Used bivariate regression for correlation analysis between inflammatory markers and lipid profiles.
Main Results:
- Elevated IL-10 and hsCRP levels were observed in all HIV patients.
- ART-naive patients had higher TNF-α and lower IL-10 and HDL-C compared to ART-experienced patients.
- A positive correlation was found between IL-10 and total cholesterol (TC); no other significant correlations were observed.
Conclusions:
- A high TNF-α/IL-10 ratio suggests increased CHD risk in ART-naive patients.
- Low HDL-C and inflammatory markers may exacerbate CHD risk.
- Unexpected findings regarding marker correlations warrant further investigation.
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