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Continuous wave laser diodes enable fast optoacoustic imaging.

Antonios Stylogiannis1, Ludwig Prade1, Andreas Buehler1

  • 1Institute of Biological and Medical Imaging, Technische Universität München, Munich, Germany and Helmholtz Zentrum München, Neuherberg, Germany.

Photoacoustics
|February 2, 2018
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Summary

Overdriving continuous wave (CW) laser diodes creates powerful, high-repetition-rate pulses for optoacoustic imaging. This cost-effective method outperforms traditional pulsed lasers, enabling new imaging applications.

Keywords:
CNR, contrast to background rationCOD, catastrophic optical damageCW, continuous waveCurrent driversDAQ, data acquisition cardFWHM, full width at half maximumLight sourcesLight-emitting diodesMIP, maximum intensity projectionNIR, near-infraredNear-infraredOPO, optical parametric oscillatorPLD, pulsed laser diodePhotoacousticSNR, signal-to-noise ratioTTL, transistor-transistor-logicUST, ultrasound transducerVIS, visibleVisible

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Area of Science:

  • Optics
  • Biomedical Engineering
  • Laser Physics

Background:

  • Pulsed laser diodes are conventional optoacoustic sources but have limitations in pulse rate and wavelength.
  • Continuous wave (CW) laser diodes offer wider wavelength availability and lower cost but are not typically used for optoacoustic imaging.

Purpose of the Study:

  • To investigate the feasibility of using overdriven CW laser diodes as effective light sources for optoacoustic imaging.
  • To assess if CW diodes can achieve high pulse rates and energy levels comparable to or exceeding pulsed laser diodes.

Main Methods:

  • Overdriving CW laser diodes with peak currents exceeding 40-fold the maximum CW rating.
  • Characterizing the output pulses in terms of duration, energy, and repetition rate.
  • Acquiring optoacoustic images of phantoms and biological tissues (mouse ear, human arm) in vivo.

Main Results:

  • Overdriven CW diodes generated ~10 ns pulses with ~200 nJ/pulse energy.
  • Achieved repetition rates exceeding 600 kHz without diode damage.
  • Successfully obtained optoacoustic images of phantoms and in vivo biological samples.

Conclusions:

  • Overdriven CW laser diodes serve as a viable, high-performance alternative to conventional pulsed laser sources for optoacoustic imaging.
  • This technique offers a smaller, less expensive, and more versatile optoacoustic light source.
  • The system demonstrates potential for advanced optoacoustic imaging and sensing applications.