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Related Experiment Video

Updated: Jan 7, 2026

Non-invasive Assessment of Microvascular and Endothelial Function
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Single-capillary endothelial dysfunction resolved by optoacoustic mesoscopy.

Hailong He1,2,3, Angelos Karlas1,2,3,4,5,6, Nikolina-Alexia Fasoula1,2

  • 1Chair of Biological Imaging, Central Institute for Translational Cancer Research (TranslaTUM), School of Medicine and Health & School of Computation, Information and Technology, Technical University of Munich, Munich, Germany.

Light, Science & Applications
|January 3, 2026
PubMed
Summary
This summary is machine-generated.

Microvascular endothelial dysfunction (MiVED) can be visualized non-invasively using fast raster-scan optoacoustic mesoscopy (fRSOM). This technology reveals early disease markers in skin capillaries, differentiating effects of smoking and cardiovascular disease on microvascular function.

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Area of Science:

  • Biomedical Optics
  • Vascular Biology
  • Medical Imaging

Background:

  • Microvascular endothelial dysfunction (MiVED) is an early indicator of endothelial impairment, preceding large artery issues.
  • Assessing MiVED offers potential for earlier cardiovascular disease (CVD) detection and stratification.
  • Current in-vivo MiVED observation is limited by technological constraints.

Purpose of the Study:

  • To investigate if accelerated ultra-wideband raster-scan optoacoustic mesoscopy (fRSOM) can visualize cutaneous MiVED at single capillary resolution.
  • To assess fRSOM's capability in capturing morphological features and dynamic responses during reactive hyperemia.
  • To achieve the most detailed observation of microvascular endothelial function to date.

Main Methods:

  • Utilized fast raster-scan optoacoustic mesoscopy (fRSOM) for non-invasive imaging of skin microvasculature.
  • Recorded morphological features and dynamic responses during post-occlusive reactive hyperemia.
  • Compared fRSOM findings in healthy individuals, smokers (N=20), and patients with atherosclerotic CVD (N=20).

Main Results:

  • fRSOM successfully measured the impact of smoking and CVD on cutaneous endothelial function.
  • Identified layer-specific effects in the dermis (sub-papillary vs. reticular), a novel finding.
  • Observed no significant structural microvascular changes in smokers or CVD patients, suggesting MiVED precedes morphological alterations.

Conclusions:

  • fRSOM provides a non-invasive method to visualize and quantify skin microvascular structure and function.
  • MiVED, assessed via fRSOM, may serve as an earlier biomarker than traditional morphological assessments.
  • fRSOM holds potential as an early detection, diagnostic, or theranostic tool for vascular conditions.