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N terminal N-methylation modulates chiral centre induced helical (CIH) peptides' biophysical properties
Wenjun Li1, Kuan Hu, Qingzhou Zhang
1The Key Laboratory of Chemical Genomics School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, China518055. yinfeng@pkusz.edu.cn lizg@pkusz.edu.cn.
Chemical Communications (Cambridge, England)
|February 2, 2018
Abstract:
The effects of N-methylation on CIH peptides' biophysical properties were systematically studied. N-Methylation at the N terminal NH could help improve the peptides' cellular uptake with a retained helical conformation. This N-methylation strategy could also be applied to longer peptides to improve their stability and cellular uptake.