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Updated: Feb 15, 2026

Neutrophil Extracellular Traps: How to Generate and Visualize Them
Published on: February 24, 2010
Neutrophil extracellular traps in ischemic AKI: new way to kill
1Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
Abstract:
Neutrophil extracellular traps, originally discovered as a mechanism to combat microbial infection, have recently been implicated in tissue damage including acute kidney injury. Raup-Konsavage et al. now present further insights to demonstrate a critical role of neutrophil peptidyl arginine deiminase-4 in the formation of neutrophil extracellular trap, inflammation, and tissue damage in ischemic acute kidney infection. Targeting peptidyl arginine deiminase-4 and/or neutrophil extracellular trap may offer a new therapeutic strategy for acute kidney infection.
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