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Published on: May 10, 2024
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Sarcopenia in diabetic nephropathy: a cross-sectional study
Meral Çeliker1, Mustafa Yavuz Selçuk1, Serdar Olt1
1Adıyaman University, Faculty of Medicine, Department of Internal Medicine, Adıyaman, Turkey.
Summary
The prevalence of sarcopenia, a loss of muscle mass, is higher in patients with diabetic nephropathy compared to healthy individuals. This study highlights a significant association between muscle wasting and diabetic kidney disease.
Area of Science:
- Endocrinology
- Nephrology
- Geriatrics
Background:
- Diabetic nephropathy is a common complication of diabetes mellitus.
- Sarcopenia is characterized by progressive loss of skeletal muscle mass and strength.
- The relationship between sarcopenia and diabetic nephropathy requires further investigation.
Purpose of the Study:
- To investigate the relationship between sarcopenia and diabetic nephropathy.
- To compare the prevalence of sarcopenia in patients with diabetic nephropathy, diabetes mellitus, and healthy controls.
Main Methods:
- Cross-sectional study including 56 diabetic patients without complications, 50 with diabetic nephropathy, and 53 healthy controls.
- Sarcopenia was diagnosed using the European Working Group on Sarcopenia in Older People (EWGSOP) criteria, including hand grip strength, 6-meter walking test, and muscle mass.
- Demographic and anthropometric measurements were collected.
Main Results:
- The frequency of sarcopenia was 15.1% in healthy controls, 21.4% in diabetes patients, and 34% in diabetic nephropathy patients (p = 0.029).
- Sarcopenia prevalence was significantly higher in patients with diabetic nephropathy compared to healthy controls (OR = 2.89).
Conclusions:
- The prevalence of sarcopenia is higher in patients with diabetic nephropathy than in healthy controls.
- Sarcopenia is a relevant condition to consider in the management of diabetic nephropathy.
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