Related Experiment Video
Updated: Feb 15, 2026

Studying Orthodontic Tooth Movement in Mice
Published on: August 2, 2024
Impaired bone healing at tooth extraction sites in CD24-deficient mice: A pilot study
Limor Avivi-Arber1, Doran Avivi2, Marilena Perez1
1Faculty of Dentistry, University of Toronto, Toronto, Canada.
Aim:
To use a micro-computed tomography (micro-CT) to quantify bone healing at maxillary first molar extraction sites, and test the hypothesis that bone healing is impaired in CD24-knockout mice as compared with wild-type C57BL/6J mice.
Materials And Methods:
Under ketamine-xylazine general anaesthesia, mice had either extraction of the right maxillary first molar tooth or sham operation. Mice were sacrificed 1 (n = 12/group), 2 (n = 6/group) or 4 (n = 6/group) weeks postoperatively. The right maxillae was disected. Micro-CT was used to quantify differences in bone microstructural features at extrction sites, between CD24-knockout mice and wild-type mice.
Results:
CD24-Knockout mice displayed impaired bone healing at extraction sites that was manifested as decreased trabecular bone density, and decreased number and thickness of trabeculae.
Conclusions:
This pilot study suggests that CD24 plays an important role in extraction socket bone healing and may be used as a novel biomarker of bone quality and potential therapeutic target to improve bone healing and density following alveolar bone injury.
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