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A case of immunoglobulin G4-related lung disease with bilateral diffuse infiltration: A case report

Ailing Liu¹, Qianwen Zhang, Bo Liu

¹Department of Pulmonary Diseases, Weihai Municipal Hospital, Weihai, Shandong, P.R. China.

|February 3, 2018

Abstract

Rationale:

Immunoglobulin (Ig) G4-related disease (IgG4-RD) is a rare and chronic progressive autoimmune disease. It is a novel clinical entity characterized by elevated serum IgG4 concentration and tissue infiltration by IgG4 plasma cells. IgG4-related lung disease (IgG4-RLD) has been described as interstitial pneumonia and inflammatory pseudotumor, with various abnormal radiographic patterns. We report a case of IgG4-related lung disease with bilateral diffuse infiltration.

Patient Concerns:

A 65-year-old woman was admitted to our hospital because of cough, sputum, and fever. Chest computed tomography (CT) revealed multifocal areas of consolidations, nodules, and ground glass opacities in both lungs. She still had fever after anti-infective therapy.

Diagnoses:

Bronchial bronchoscopy and percutaneous lung biopsy were performed, resulted in a pathological diagnosis of IgG4-RLD.

Interventions:

The patient was started on oral prednisolone 30 mg/day for 28 days, and then was gradually tapered.

Outcomes:

After one week treatment, the temperature was stable, CT showed significant improvement in the areas of consolidations and nodules.

Lessons:

It is a typical case of IgG4-RLD. This case indicated that suggestive evidence, radiological appearances, serum tests, pathological characteristics, and classic therapy IgG4-RLD. It is a rare disease that needs our more attention in future.

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