Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

7.7K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
7.7K
Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

Imaging Studies II: Positron Emission Tomography and Scintigraphy

619
Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
619
Obesity01:24

Obesity

1.4K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.4K
Emission Spectra02:39

Emission Spectra

76.7K
When solids, liquids, or condensed gases are heated sufficiently, they radiate some of the excess energy as light. Photons produced in this manner have a range of energies, and thereby produce a continuous spectrum in which an unbroken series of wavelengths is present.
76.7K
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

269
In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...
269
Computed Tomography01:10

Computed Tomography

9.0K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
9.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brain Serotonin Transporter Is Elevated in Obesity: Bayesian and Frequentist Meta-Analyses.

Diabetes, obesity & metabolism·2026
Same author

Brain Amyloid Deposition Is Negatively Associated with Cardiac Amyloid Retention in Apo E4 Carriers: A Pilot Study.

Molecular imaging and biology·2026
Same author

High-Speed Instance Segmentation for Endoscopic Spine Surgery: Multicenter Validation and Inference Speed Evaluation.

Global spine journal·2026
Same author

Evaluation of Trabecular Bone Score and Bone Mineral Density in Patients with Primary Hyperparathyroidism under 50 Years Old.

Journal of bone metabolism·2026
Same author

Metabolic networks in the tumor microenvironment: roles of amino acid and lipid metabolism pathways in cancer progression and therapy.

Experimental & molecular medicine·2026
Same author

A novel disposition index without insulin is an earlier and sensitive predictor of type 2 diabetes than current diagnostic criteria.

Diabetes research and clinical practice·2026

Related Experiment Video

Updated: Feb 15, 2026

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
08:36

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

Published on: June 7, 2024

702

Obesity and Brain Positron Emission Tomography.

Kyoungjune Pak1, Seong-Jang Kim2, In Joo Kim1

  • 11Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, Busan, South Korea.

Nuclear Medicine and Molecular Imaging
|February 3, 2018
PubMed
Summary

Positron emission tomography (PET) reveals brain differences in obese individuals, including altered blood flow and metabolism. These findings enhance our understanding of obesity

Keywords:
BrainObesityPositron-emission tomography

More Related Videos

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

4.4K
Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production
10:20

Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production

Published on: October 26, 2018

11.9K

Related Experiment Videos

Last Updated: Feb 15, 2026

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner
08:36

Multi-Tracer Studies of Brain Oxygen and Glucose Metabolism Using a Time-of-Flight Positron Emission Tomography-Computed Tomography Scanner

Published on: June 7, 2024

702
High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
11:09

High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals

Published on: December 16, 2022

4.4K
Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production
10:20

Automation of a Positron-emission Tomography PET Radiotracer Synthesis Protocol for Clinical Production

Published on: October 26, 2018

11.9K

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Metabolic Disorders

Background:

  • Obesity stems from chronic energy imbalance, influenced by homeostatic and non-homeostatic factors.
  • Understanding the brain's role in regulating food intake is crucial for addressing the obesity epidemic.

Purpose of the Study:

  • To investigate the neural underpinnings of obesity using advanced brain imaging techniques.
  • To explore how brain activity and receptor availability differ in obese versus non-obese individuals.

Main Methods:

  • Utilized positron emission tomography (PET) with various radiopharmaceuticals.
  • Employed 15O-H2 PET to assess regional cerebral blood flow (rCBF) and neuronal activity.
  • Applied 18F-fluorodeoxyglucose PET to measure brain metabolic activity.
  • Investigated dopamine receptor (DR) availability using DR PET.

Main Results:

  • Obese subjects showed increased rCBF in the insula (gustatory cortex).
  • Higher metabolic activity was observed in the postcentral gyrus, with lower activity in the prefrontal and anterior cingulate cortex in obese individuals.
  • Obese subjects exhibited lower dopamine receptor availability, potentially driving overeating.

Conclusions:

  • Brain PET imaging reveals significant differences in cerebral blood flow, metabolism, and dopamine receptor availability associated with obesity.
  • These neurobiological alterations provide insights into the brain's complex relationship with obesity.
  • Findings suggest potential targets for novel obesity treatments by addressing brain circuitry.