Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Global Climate Change01:50

Global Climate Change

29.1K
Throughout its ~4.5 billion year history, the Earth has experienced periods of warming and cooling. However, the current drastic increase in global temperatures is well outside of the Earth’s cyclic norms, and evidence for human-caused global climate change is compelling. Paleoclimatology, the study of ancient climate conditions, provides ample evidence for human-caused global climate change by comparing recent conditions with those in the past.
29.1K
Introduction to Global Positioning System01:30

Introduction to Global Positioning System

610
The Global Positioning System (GPS) revolutionized positioning on Earth, providing precise location data through satellite ranging. The GPS system was developed in 1978 by the U.S. Department of Defense  for military use, and it became available for civilian applications in 1983, transforming fields including navigation, fleet management, and time synchronization for telecommunications systems.GPS consists of satellites in medium Earth orbit, about 20,200 kilometers above the surface,...
610
Errors in Global Positioning System01:26

Errors in Global Positioning System

364
Global Positioning System (GPS) technology has revolutionized navigation and positioning, but its accuracy is often compromised by various errors. These errors, stemming from environmental, satellite, and receiver-related factors, require careful mitigation to ensure reliable performance across applications.Atmospheric ErrorsGPS signals travel through the Earth’s ionosphere and troposphere, introducing delays which affect accuracy. The ionosphere is strongly influenced by charged particles,...
364
Global Regulatory Systems01:28

Global Regulatory Systems

732
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
732
Self-Evaluation: Self-Enhancement and Self-Verification03:00

Self-Evaluation: Self-Enhancement and Self-Verification

5.8K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
5.8K
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

4.3K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
4.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Baseline Descending Aortic Diameter Drives Long-Term Failure of Conservative Management in Uncomplicated Type B Aortic Dissection.

Annals of vascular surgery·2026
Same author

Acute renal failure after dietary change - a case report.

BMC nephrology·2026
Same author

First Results on the Search for Lepton Number Violating Neutrinoless Double-β Decay with the LEGEND-200 Experiment.

Physical review letters·2026
Same author

Definition of parameters and thresholds to detect MYCN amplification in retinoblastomas.

Virchows Archiv : an international journal of pathology·2025
Same author

Final Results of the Majorana Demonstrator's Search for Double-Beta Decay of ^{76}Ge to Excited States of ^{76}Se.

Physical review letters·2025
Same author

Population genetic structure in two contrasting human-altered environments of yellow pygmy rice rat Oligoryzomys flavescens.

Oecologia·2025

Related Experiment Video

Updated: Feb 15, 2026

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
07:23

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury

Published on: March 7, 2022

7.3K

Enhanced Cardiac S100A1 Expression Improves Recovery from Global Ischemia-Reperfusion Injury.

S Jungi1, X Fu1, A Segiser1

  • 1Department of Cardiovascular Surgery, Inselspital University Hospital, University of Bern, 3010, Bern, Switzerland.

Journal of Cardiovascular Translational Research
|February 3, 2018
PubMed
Summary

Cardiomyocyte-specific S100A1 overexpression protects the heart from ischemia-reperfusion injury (IRI). This gene therapy improved heart function and reduced tissue damage, showing promise for treating heart failure.

Keywords:
CardioprotectionInotropic therapyIschemia-reperfusion injuryS100A1

More Related Videos

Model of Ischemia and Reperfusion Injury in Rabbits
06:11

Model of Ischemia and Reperfusion Injury in Rabbits

Published on: November 3, 2023

1.8K
Induction and Assessment of Ischemia-reperfusion Injury in Langendorff-perfused Rat Hearts
07:58

Induction and Assessment of Ischemia-reperfusion Injury in Langendorff-perfused Rat Hearts

Published on: July 27, 2015

24.2K

Related Experiment Videos

Last Updated: Feb 15, 2026

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury
07:23

Improved Rodent Model of Myocardial Ischemia and Reperfusion Injury

Published on: March 7, 2022

7.3K
Model of Ischemia and Reperfusion Injury in Rabbits
06:11

Model of Ischemia and Reperfusion Injury in Rabbits

Published on: November 3, 2023

1.8K
Induction and Assessment of Ischemia-reperfusion Injury in Langendorff-perfused Rat Hearts
07:58

Induction and Assessment of Ischemia-reperfusion Injury in Langendorff-perfused Rat Hearts

Published on: July 27, 2015

24.2K

Area of Science:

  • Cardiology
  • Molecular Biology
  • Biochemistry

Background:

  • Gene-targeted therapy using the Ca2+-sensor protein S100A1 shows promise for heart failure.
  • S100A1 influences cardiac metabolism and mitochondrial function, suggesting a cardioprotective role.

Purpose of the Study:

  • To investigate the cardioprotective effect of S100A1 overexpression in myocardial ischemia-reperfusion injury (IRI).

Main Methods:

  • Isolated rat hearts with cardiomyocyte-specific S100A1 overexpression were subjected to global ischemia followed by reperfusion.
  • Hemodynamic parameters, cardiac enzyme release, and tissue markers were analyzed.

Main Results:

  • S100A1 overexpressing hearts exhibited superior hemodynamic recovery compared to controls.
  • Reduced levels of Troponin T and lactate dehydrogenase, along with higher phosphocreatine content, indicated less tissue necrosis.
  • Decreased levels of the pro-apoptotic transcription factor FoxO were observed.

Conclusions:

  • S100A1 overexpression demonstrates a significant cardioprotective effect against global IRI.
  • This study provides the first evidence of S100A1's protective role in myocardial IRI, supporting its potential therapeutic application.