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Prolonged dipyridamole administration reduces myocardial perfusion defects in experimental chronic Chagas

Denise Mayumi Tanaka1, Luciano Fonseca Lemos de Oliveira1, José Antônio Marin-Neto1

  • 1Medical School of Ribeirao Preto, University of São Paulo, Sao Paulo, Brazil.

Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology
|February 3, 2018
PubMed
Abstract

Insights

Dipyridamole reduced myocardial perfusion defects in a hamster model of chronic Chagas cardiomyopathy. This suggests that these defects represent viable, hypoperfused heart muscle, not irreversible damage.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Myocardial perfusion defects (MPD) are common in chronic Chagas cardiomyopathy (CCC) and may contribute to heart damage.
  • Coronary microvascular dysfunction is a key factor in CCC-related MPD.

Purpose of the Study:

  • To determine if MPD precede left ventricular systolic dysfunction in experimental CCC.
  • To test if prolonged dipyridamole (DIPY) treatment can reduce MPD in a hamster model of CCC.

Main Methods:

  • Female hamsters infected with T. cruzi were treated with DIPY or placebo.
  • Echocardiography and myocardial perfusion scintigraphy were used to assess cardiac function and perfusion.
  • Histology was performed to evaluate inflammation and fibrosis.

Main Results:

  • At baseline, infected hamsters showed significantly larger perfusion defects than controls.
  • After 30 days of treatment, DIPY significantly reduced perfusion defects in infected hamsters.
  • Left ventricular ejection fraction decreased in both DIPY-treated and placebo-treated infected hamsters.
  • Histology revealed increased inflammation and fibrosis in infected hamsters, with no difference between treatment groups.

Conclusions:

  • Prolonged dipyridamole use reduced rest myocardial perfusion defects in experimental CCC.
  • These findings suggest that MPD in this model represent viable, hypoperfused myocardium.
Keywords:
Chagas cardiomyopathycoronary microcirculationdipyridamolehamstersventricular dysfunction

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