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Microcomputer-based nonlinear regression analysis of ligand-binding data: application of Akaike's information
Japanese Journal of Pharmacology
|February 1, 1986
Abstract:
Akaike's information criterion (AIC) (Akaike, H., IEEE Trans. Automat. Contr. AC-19, 716-723 (1974)) was applied to estimate statistically the number of classes of binding sites from ligand-binding data. Several sets of data were analyzed by both the AIC method and the F-test method. Good agreement was obtained between results from both methods. The present results suggest that the AIC method can be a good alternative to the F-test to estimate the number of classes of sites.