Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Determining Order of Reaction02:53

Determining Order of Reaction

62.7K
Rate laws describe the relationship between the rate of a chemical reaction and the concentration of its reactants. In a rate law, the rate constant k and the reaction orders are determined experimentally by observing how the rate of reaction changes as the concentrations of the reactants are changed. A common experimental approach to the determination of rate laws is the method of initial rates. This method involves measuring reaction rates for multiple experimental trials carried out using...
62.7K
Determination01:51

Determination

21.0K
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
21.0K
Determining the pH of Salt Solutions04:08

Determining the pH of Salt Solutions

48.3K
The pH of a salt solution is determined by its component anions and cations. Salts that contain pH-neutral anions and the hydronium ion-producing cations form a solution with a pH less than 7. For example, in ammonium nitrate (NH4NO3) solution, NO3− ions do not react with water whereas NH4+ ions produce the hydronium ions resulting in the acidic solution.  In contrast, salts that contain pH-neutral cations and the hydroxide ion-producing anions form a solution with a pH greater than 7. For...
48.3K
Rate-Determining Steps03:08

Rate-Determining Steps

37.5K
Relating Reaction Mechanisms
In a multistep reaction mechanism, one of the elementary steps progresses significantly slower than the others. This slowest step is called the rate-limiting step (or rate-determining step). A reaction cannot proceed faster than its slowest step, and hence, the rate-determining step limits the overall reaction rate.
The concept of rate-determining step can be understood from the analogy of a 4-lane freeway with a short-stretch of traffic-bottleneck caused due to...
37.5K
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

1.2K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.2K
Experimental Determination of Chemical Formula02:37

Experimental Determination of Chemical Formula

47.8K
The elemental makeup of a compound defines its chemical identity, and chemical formulas are the most concise way of representing this elemental makeup. When a compound’s formula is unknown, measuring the mass of its constituent elements is often the first step in determining the formula experimentally.
47.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In sphincter of Oddi patients, amelioration of pain is primarily associated with common bile duct dilation rather than hepatobiliary scintigraphy excretion time or alanine amino transferase - a single centre, retrospective study.

Clinical physiology and functional imaging·2026
Same author

[Late sequelae after gastrointestinal surgery in adults].

Ugeskrift for laeger·2026
Same author

Perioperative antibiotics for mild or moderate acute cholecystitis - A systematic review and meta-analysis.

American journal of surgery·2026
Same author

Dysfunction of Biliary Sphincter of Oddi-Clinical, Diagnostic and Treatment Challenges.

Journal of clinical medicine·2023
Same author

The Symptomatic Outcomes of Cholecystectomy for Gallstones.

Journal of clinical medicine·2023
Same author

One-step laparoscopic cholecystectomy with common bile duct exploration and stone extraction versus two-step endoscopic retrograde cholangiography with stone extraction plus laparoscopic cholecystectomy for patients with common bile duct stones: a randomised feasibility and pilot clinical trial-the preGallStep trial.

Pilot and feasibility studies·2023

Related Experiment Video

Updated: Feb 15, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

34.9K

New determinants for gallstone disease?
.

Daniel Mønsted Shabanzadeh1

  • 1daniel.moensted.shabanzadeh@regionh.dk.

Danish Medical Journal
|February 3, 2018
PubMed
Summary

This study identified new determinants for gallstone disease, including male hormones, and confirmed known risk factors like BMI and cholesterol. Findings support interventions targeting weight, cholesterol, and alcohol for gallstone prevention.

Area of Science:

  • Gastroenterology
  • Epidemiology
  • Endocrinology

Background:

  • Gallstone disease is common in Northern Europe, with cholecystectomy being a frequent surgery.
  • Established risk factors include bile cholesterol saturation, gallbladder function, and bile salt metabolism.
  • Previous research was limited by study design and focusing only on symptomatic gallstone disease.

Purpose of the Study:

  • To identify new and confirm existing determinants of gallstone disease in a general population.
  • To link identified determinants to known biological mechanisms of gallstone formation.
  • To evaluate lifestyle factors and biomarkers associated with gallstone disease.

Main Methods:

  • Utilized a Danish general-population cohort with multiple ultrasound screenings for gallstone disease.

More Related Videos

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease
03:20

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Published on: September 22, 2023

2.4K
High Content Screening in Neurodegenerative Diseases
13:32

High Content Screening in Neurodegenerative Diseases

Published on: January 6, 2012

18.1K

Related Experiment Videos

Last Updated: Feb 15, 2026

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
09:34

Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

34.9K
Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease
03:20

Author Spotlight: Exploring Non-Motor Symptoms in Parkinson's Disease

Published on: September 22, 2023

2.4K
High Content Screening in Neurodegenerative Diseases
13:32

High Content Screening in Neurodegenerative Diseases

Published on: January 6, 2012

18.1K
  • Analyzed temporal associations for incident gallstone disease with various factors.
  • Examined cross-sectional associations with biomarkers, genetic risk, and lifestyle factors.

    • Main Results:

    • Confirmed risk factors: female sex, BMI, non-HDL cholesterol, alcohol consumption, hormone replacement therapy.
    • Identified new determinants: testosterone and sex hormone-binding globulin (SHBG) in males.
    • Found associations with insulin resistance, systemic inflammation, genetic risk, and renal function biomarkers.

    Conclusions:

    • Identified determinants are linked to core gallstone formation mechanisms.
    • Lifestyle factors like smoking and diet were not confirmed as determinants in this study.
    • Future research should focus on objective measures for lifestyle factors and explore hormonal and inflammatory markers.