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Clinical Course and Outcome of Childhood Acquired Platelet Dysfunction with Eosinophilia

Thirachit Chotsampancharoen1, Pornpun Sripornsawan, Sarapee Duangchu

  • 1Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Thailand.

Acta Haematologica
|February 3, 2018
PubMed

Insights

Acquired platelet dysfunction with eosinophilia (APDE) is a rare pediatric syndrome. This study found APDE typically has a benign course with spontaneous remission and no severe bleeding events.

Area of Science:

  • Pediatric Hematology
  • Clinical Medicine
  • Immunology

Background:

  • Acquired platelet dysfunction with eosinophilia (APDE) is a transient condition.
  • It presents with platelet dysfunction and eosinophilia in children.

Purpose of the Study:

  • To investigate the clinical course and outcomes of pediatric APDE.
  • To identify factors influencing remission and disease prognosis.

Main Methods:

  • Retrospective review of hospital records for 69 children diagnosed with APDE.
  • Analysis of clinical presentation, laboratory findings, treatment, and remission times.

Main Results:

  • Patients presented with ecchymoses but no serious bleeding.
  • Abnormal platelet morphology was common; parasitic infestation found in 38%.
  • Median remission time was 2.6 months, with high remission rates (94% by 12 months).

Conclusions:

  • APDE in children is generally transient and self-limiting.
  • The syndrome has a benign clinical course with spontaneous remission.
  • No significant determinants for remission time were identified.

Keywords:
Acquired platelet dysfunction with eosinophiliaBleeding disorder with ecchymosisChildhoodClinical outcomeEcchymosis with platelet dysfunction

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