Risperidone Treatment for Irritability in Fragile X Syndrome
Kelli C Dominick1, Logan K Wink1, Ernest V Pedapati1
11 Division of Child and Adolescent Psychiatry, Cincinnati Children's Hospital Medical Center , Cincinnati, Ohio.
Journal of Child and Adolescent Psychopharmacology
|February 3, 2018
Summary
Risperidone monotherapy for irritability in Fragile X syndrome (FXS) showed limited effectiveness in this study. Further research is needed to understand its role in managing FXS symptoms.
Area of Science:
- Neuroscience
- Psychiatry
- Genetics
Background:
- Fragile X syndrome (FXS) is a genetic disorder associated with behavioral challenges, including irritability.
- Irritability is a common and disruptive symptom in individuals with FXS.
- Current treatment options for FXS-related irritability are limited.
Purpose of the Study:
- To assess the effectiveness of risperidone as a sole antipsychotic therapy for irritability in patients with Fragile X syndrome.
- To evaluate risperidone's efficacy in a naturalistic outpatient clinical setting.
- To analyze treatment outcomes in male patients with FXS receiving risperidone.
Main Methods:
- Retrospective analysis of a prospectively collected database of patients with developmental disabilities.
- Inclusion of 21 male patients diagnosed with Fragile X syndrome.
- Determination of treatment duration, dosage, and Clinical Global Impressions-Improvement (CGI-I) scores.
Main Results:
- The mean age of participants at treatment initiation was 14.0 years.
- The average duration of risperidone treatment was 22 months, with a mean final dose of 2.5 mg/day.
- Seven out of 21 (33.33%) participants were classified as treatment responders based on CGI-I scores.
Conclusions:
- Risperidone may offer some benefit for irritability in males with Fragile X syndrome.
- The overall effectiveness of risperidone monotherapy in this study was less pronounced than in previous reports.
- Differences in outcome measures and patient characteristics may explain the observed effectiveness in this sample.
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