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Mouse models in squamous cell lung cancer: impact for drug discovery

Aditi P Singh1, Diego Adrianzen Herrera1, Yifei Zhang2

  • 1a Department of Oncology , Montefiore Medical Center/Albert Einstein College of Medicine , Bronx , NY , USA.

Expert Opinion on Drug Discovery
|February 3, 2018
PubMed
Abstract

Insights

Developing effective treatments for squamous cell lung cancer (SQCLC) is challenging due to limited preclinical models. This review explores existing mouse models for SQCLC drug discovery and chemoprevention.

Area of Science:

  • Oncology
  • Pulmonology
  • Genetics

Background:

  • Squamous cell lung cancer (SQCLC) is a major subtype of non-small cell lung cancer (NSCLC) with few therapeutic options.
  • Its development involves a multistep process linked to chronic tobacco exposure.
  • Limited validated driver mutations hinder targeted therapy development for SQCLC.

Purpose of the Study:

  • To discuss the pathophysiology and molecular basis of SQCLC that impede animal model development.
  • To explore the utility and drawbacks of current mouse models for SQCLC.
  • To illustrate the application of these models in drug discovery and chemoprevention.

Main Methods:

  • Review of existing literature on SQCLC pathophysiology and molecular genetics.
  • Analysis of various preclinical murine models for SQCLC.
  • Discussion of challenges and successes in SQCLC model development.

Main Results:

  • Challenges in SQCLC model development include lack of validated driver alterations, unclear cell of origin, and difficulty replicating the tumor microenvironment.
  • Patient-Derived Xenografts (PDXs) and Genetically Engineered Mouse Models (GEMMs) show promise for SQCLC research.
  • Existing models offer potential for testing novel therapeutics and chemopreventive strategies.

Conclusions:

  • Further development of SQCLC animal models is crucial for understanding carcinogenesis and metastasis.
  • Advanced SQCLC models are needed to accelerate the testing of new therapeutic strategies.
  • Improved preclinical models will aid in overcoming therapeutic limitations in squamous cell lung cancer.
Keywords:
Squamous cell lung cancermouse modelsmurine modelsxenografts

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